Protein Details: Potassium voltage-gated channel subfamily H member 2
Protein ID
ICDB_Pro_0177
Protein Name
Potassium voltage-gated channel subfamily H member 2
Gene Name
KCNH2; ERG
Organism
Cavia porcellus (Guinea pig)
Length
162 amino acids
AlphaFoldDB
AF-O08703-F1-model_v4.pdb
Function
Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (By similarity)
Sequence
AVWDWLILLLVIYTAVFTPYSAAFLLKEPEEDAQTADCGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWY
PDB Structures
Ligand Binding
Binding Site
Disease
Location
Highly expressed in heart and brain.
DOI ID
10.1161/01.res.80.2.261